Agomelatine
Keeb kwm
Agomelatine yog ib qho agonist ntawm melatonin receptors thiab tus antagonist ntawm serotonin 5-HT2C receptor nrog Ki qhov txiaj ntsig ntawm 0.062nM thiab 0.268nM thiab IC50 tus nqi ntawm 0.27μM, feem rau MT1, MT2 thiab 5-HT2C1.
Agomelatine yog ib qho tshuaj tiv thaiv kev nyuaj siab tshwj xeeb thiab yog tsim los rau kev kho mob ntawm kev nyuaj siab loj (MDD). Agomelatine yog xaiv tawm tsam 5-HT2C. Nws qhia tau hais tias tsawg affinities rau cloned tib neeg 5-HT2A thiab 5-HT1A. Rau melatonin receptors, agomelatine qhia tau hais tias zoo sib xws rau cloned tib neeg MT1 thiab MT2 nrog Ki qhov tseem ceeb ntawm 0.09nM thiab 0.263nM, feem. Hauv kev tshawb fawb hauv vivo, agomelatin ua rau nce qib ntawm dopamine thiab noradrenaline los ntawm kev thaiv cov kev tawm tswv yim ntawm 5-HT2C. Ntxiv mus, kev tswj hwm ntawm agomelatin tiv thaiv qhov kev ntxhov siab vim txo qis hauv sucrose noj hauv cov qauv nas ntawm kev nyuaj siab. Tsis tas li ntawd, agomelatine ua rau txo qhov kev ntxhov siab ntawm kev ntxhov siab hauv tus nas qauv ntawm kev ntxhov siab [1].
Cov ntaub ntawv:
[1] Zupancic M, Guilleminault C. Agomelatine. CNS tshuaj, 2006, 20(12): 981-992.
Cov qauv tshuaj
Tswv yim18Quality Consistency Evaluation tej yaam num uas tau pom zoo4, thiab6tej yaam num raug tso cai.
Advanced thoob ntiaj teb kev tswj hwm qhov system tau tso lub hauv paus ruaj khov rau kev muag khoom.
Kev saib xyuas zoo khiav los ntawm tag nrho lub neej voj voog ntawm cov khoom kom ntseeg tau tias qhov zoo thiab kho cov nyhuv.
Pab Pawg Kev Tswj Xyuas Kev Tswj Xyuas Kev Ua Haujlwm txhawb nqa qhov kev xav tau zoo thaum lub sijhawm thov thiab sau npe.
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