Keeb kwm

Atorvastatin Calcium yog ib qho muaj zog inhibitor ntawm HMG-CoA reductase nrog IC50 tus nqi ntawm 150 nM [1].
HMG-CoA reductase yog cov enzyme tseem ceeb ntawm txoj kev mevalonate uas tsim cov roj cholesterol. HMG-CoA yog qhov txo qis enzyme thiab tseem ceeb rau kev txo qis cov roj cholesterol. HMG-CoA reductase nyob rau hauv endoplasmic reticulum thiab muaj yim transmembrane domains. Cov inhibitors ntawm HMG-CoA reductase tuaj yeem ua rau LDL (tsis tshua muaj lipoprotein) receptors qhia hauv daim siab. Nws ua rau kom nce qib catabolism ntawm plasma LDL thiab txo qis cov roj cholesterol hauv cov ntshav uas yog qhov tseem ceeb ntawm kev txiav txim siab ntawm atherosclerosis. HMG-CoA reductase ua lub luag haujlwm tseem ceeb hauv kev tsim cov roj cholesterol. HMG-CoA yog lub hom phiaj rau cov tshuaj txo cov roj cholesterol. HMG-CoA reductase kuj yog ib qho enzyme tseem ceeb rau kev loj hlob. Kev ua haujlwm ntawm HMG-CoA reductase muaj feem cuam tshuam rau cov kab mob ntawm cov cell migration defects. Inhibition ntawm nws cov dej num tuaj yeem ua rau intracerebral hemorrhage[1].
Atorvastatin yog HMG-CoA reductase inhibitor nrog IC50 tus nqi ntawm 154 nM. Nws muaj txiaj ntsig zoo hauv kev kho qee yam dyslipidemias thiab hypercholesterolemia [1]. Kev kho Atorvastatin ntawm 40 mg txo cov roj cholesterol tag nrho ntawm 40% tom qab 40 hnub.[1] Nws kuj tseem siv los kho cov neeg mob coronary lossis mob stroke nrog cov qib roj cholesterol ib txwm muaj.[2] Atorvastatin kuj txo qis qis lipoprotein apheresis hauv cov neeg mob los ntawm inducing LDL-receptors qhia.
Nws yog metabolized rau ntau yam metabolites uas yog ib qho tseem ceeb rau cov nyhuv ntawm cov tshuaj kho los ntawm CYP3A4 (cytochrome P450 3A4).[3]
Cov ntaub ntawv:
[1]. van Dam M, Zwart M, de Beer F, Smelt AH, Prins MH, Trip MD, Havekes LM, Lansberg PJ, Kastelein JJ: Kev siv tau ntev thiab kev nyab xeeb ntawm atorvastatin hauv kev kho mob hnyav hom III thiab ua ke dyslipidaemia. Heart 2002, 88(3:234-238).
[2]. Sever PS, Dahlof B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes GT et al: Tiv thaiv kev mob plawv thiab mob stroke nrog atorvastatin hauv cov neeg mob ntshav siab uas muaj qhov nruab nrab lossis qis dua. - nruab nrab cov roj cholesterol ntau, hauv Anglo-Scandinavian Cardiac Outcomes Trial - Lipid Lowering Caj Npab (ASCOT-LLA): ib qho kev sib tw multicentre randomized tswj kev sim. Lancet 2003, 361 (9364): 1149-1158.
[3]. Lennernas H: Clinical pharmacokinetics ntawm atorvastatin. Clin Pharmacokinet 2003, 42(13): 1141-1160.

Cov qauv tshuaj