Keeb kwm

Canagliflozin yog ib qho tshiab, muaj zog, thiab muaj kev xaiv sodium glucose co-transporter (SGLT) 2 inhibitor [1]. Nws tau raug pov thawj tias Canagliflozin tuaj yeem ua rau cov zis tso zis ntau ntxiv los ntawm kev txo qis cov piam thaj hauv lub raum thiab los ntawm kev txo qis cov piam thaj rov qab nqus [2].

Canagliflozin tau pom tias inhibit Na +-mediated 14C-AMG intakes hauv CHO-hSGLT2, CHO-rat SGLT2 thiab CHO-nas SGLT2 nrog IC50 qhov tseem ceeb ntawm 4.4, 3.7 thiab 2.0 nM, raws li [1].

Canagliflozin tau tshaj tawm los txo cov ntshav qabzib (BG) qib koob tshuaj-nyob ntawm ob qho tib si db / db nas thiab Zucker ntshav qab zib fatty (ZDF) nas. Tsis tas li ntawd, canagliflozin tau ua pov thawj los txo qhov kev sib pauv ua pa, thiab lub cev hnyav hauv DIO nas thiab ZDF nas [1].

Canagliflozin tuaj yeem noj hauv qhov ncauj [1].

Cov ntaub ntawv:
[1] Liang Y1, Arakawa K, Ueta K, Matsushita Y, Kuriyama C Martin T, Du F, Liu Y, Xu J, Conway B, Conway J, Polidori D, Txoj Kev K, Demarest K. Cov nyhuv ntawm canagliflozin ntawm lub raum pib. rau cov piam thaj, glycemia, thiab lub cev hnyav hauv cov qauv tsiaj thiab cov ntshav qab zib. PLoS Ib. 2012; 7(2):e30555
[2] Sarnoski-Brocavich S, Hilas O. Canagliflozin (Invokana), a Novel Oral Agent for Type-2 Diabetes. P T. 2013 Nov; 38(11:656-66

Khoom Citation

Bahia Abbas Moussa, Marianne Alphonse Mahrouse, et al. "Txoj kev daws teeb meem sib txawv rau kev tswj hwm ntawm kev sib tshooj spectra: Daim ntawv thov rau kev txiav txim siab tshiab co-formulated hypoglycemic tshuaj nyob rau hauv lawv cov tshuaj noj ua ke." Spectrochimica Acta Part A: Molecular thiab Biomolecular Spectroscopy Muaj nyob online 20 Lub Rau Hli 2018.

Cov qauv tshuaj