Cov tshuaj no yog siv los ntawm cov poj niam los pab txo qhov mob nruab nrab mus rau qhov mob hnyav vim yog mob hu ua endometriosis.
Tej zaum kho: endometriosis
Hom Lub Npe: Orilissa
Yam tshuaj: LHRH (GnRH) antagonists
Muaj: Yuav tsum tau muab tshuaj
Cev xeeb tub: Tsis txhob siv thaum cev xeeb tub
Lactation: Tham nrog kws kho mob ua ntej siv

Elagolix yog qhov ncauj bioavailable, thib ob tiam, tsis yog peptide raws li, me me molecule compound thiab xaiv gonadotropin-tso hormone (GnRH; LHRH) receptor antagonist, muaj peev xwm tsim cov tshuaj hormones inhibitory kev ua haujlwm. Raws li kev tswj hwm qhov ncauj, elagolix sib tw nrog GnRH rau receptor binding thiab inhibits GnRH receptor signaling nyob rau hauv lub anterior pituitary caj pas. Qhov no inhibits lub secretion ntawm luteinizing hormone (LH) thiab follicle stimulating hormone (FSH). Hauv cov txiv neej, qhov inhibition ntawm LH secretion tiv thaiv kev tso tawm ntawm testosterone. Hauv cov poj niam, inhibition ntawm FSH thiab LH tiv thaiv kev tsim cov tshuaj estrogen los ntawm zes qe menyuam. Inhibition ntawm GnRH signaling tuaj yeem kho lossis tiv thaiv cov tsos mob ntawm kev sib deev hormone-dependent kab mob.

Elagolix yog qhov ncauj, nonsteroidal gonadotropin tso cov tshuaj hormone (GnRH) antagonist uas txo cov tshuaj estrogen thiab siv los kho cov mob endometriosis ntawm cov poj niam. Elagolix txoj kev kho yog txuam nrog tus nqi qis ntawm cov enzymes nce siab thaum lub sijhawm kho thiab tseem tsis tau txuas nrog rau cov xwm txheej ntawm kev mob siab rau lub siab.

Elagolix tau siv rau hauv kev sim kawm txog kev tshawb fawb thiab kev kho mob ntawm Endometriosis, Folliculogenesis, Uterine Fibroids, Hnyav Uterine Bleeding, thiab Heavy Menstrual Bleeding. Raws li ntawm 24 Lub Xya Hli 2018, txawm li cas los xij, US Food and Drug Administration (FDA) tau pom zoo rau AbbVie's elagolix raws li lub npe Orilissa ua thawj thiab tsuas yog qhov ncauj gonadotropin-tso tshuaj hormone (GnRH) antagonist tshwj xeeb tsim rau cov poj niam uas muaj mob hnyav rau endometriosis. Nws tau raug txiav txim siab tias endometriosis yog ib qho ntawm cov kab mob gynecologic tshaj plaws hauv Tebchaws Meskas. Tshwj xeeb, kev kwv yees qhia tias ib ntawm kaum tus poj niam ntawm lub hnub nyoog yug me nyuam raug cuam tshuam los ntawm endometriosis thiab muaj cov tsos mob mob hnyav. Ntxiv mus, cov poj niam uas raug cuam tshuam los ntawm tus mob no tuaj yeem raug kev txom nyem mus txog rau rau mus rau kaum xyoo thiab mus ntsib ntau tus kws kho mob ua ntej tau txais kev kuaj mob kom raug. Tom qab ntawd, raws li Orilissa (elagolix) tau pom zoo los ntawm FDA nyob rau hauv qhov kev tshuaj xyuas ua ntej, qhov kev pom zoo tshiab no tau muab rau cov kws kho mob lwm qhov kev xaiv tseem ceeb rau kev kho cov kev xav tau ntawm cov poj niam uas cuam tshuam los ntawm endometriosis, nyob ntawm seb lawv hom tshwj xeeb thiab qhov mob ntawm endometriosis. .

Cov qauv tshuaj