Rosuvastatin (hom npe Crestor, ua lag luam los ntawm AstraZeneca) yog ib qho ntawm cov tshuaj statin feem ntau siv.Zoo li lwm yam tshuaj statins, rosuvastatin tau muab tshuaj los txhim kho tib neeg cov ntshav lipid thiab txo qis kev pheej hmoo ntawm cov hlab plawv.

Nyob rau hauv thawj xyoo caum los yog li ntawd rosuvastatin nyob rau hauv kev ua lag luam, nws tau dav touted raws li ib tug "tiam thib peb-tiam statin," thiab yog li ua tau zoo dua thiab tej zaum yuav ua rau muaj kev phiv tsawg tshaj li lwm yam tshuaj statin.Raws li lub xyoo dhau los thiab raws li cov pov thawj los ntawm kev sim tshuaj tau nce, ntau qhov kev txaus siab thaum ntxov rau qhov tshwj xeeb statin tau dhau los ua kev hloov pauv.

Tam sim no cov kws tshaj lij feem ntau xav txog cov kev pheej hmoo thiab cov txiaj ntsig ntawm rosuvastatin kom zoo ib yam li lwm cov statins.Txawm li cas los xij, muaj qee qhov xwm txheej kho mob uas rosuvastatin yuav nyiam.

Kev siv rosuvastatin

Cov tshuaj statin tau tsim los txo cov roj cholesterol.Cov tshuaj no khi kev sib tw rau lub siab enzyme hu ua hydroxymethylglutaryl (HMG) CoA reductase.HMG CoA reductase plays lub luag haujlwm txwv tus nqi hauv kev tsim cov roj cholesterol los ntawm lub siab.

Los ntawm thaiv HMG CoA reductase, statins tuaj yeem txo qis LDL ("phem") cov roj cholesterol ntau hauv daim siab, thiab yog li tuaj yeem txo qis LDL cov roj cholesterol hauv cov ntshav ntau li 60%.Tsis tas li ntawd, statins txo qis cov ntshav triglyceride hauv cov ntshav (kwv yees li 20-40%), thiab ua kom me me (li 5%) hauv cov ntshav HDL cholesterol ("cov roj cholesterol zoo").

Nrog rau kev zam ntawm PCSK9 inhibitors tsis ntev los no, statins yog cov tshuaj txo cov roj cholesterol ntau tshaj plaws.Tsis tas li ntawd, nyob rau hauv sib piv rau lwm cov chav kawm ntawm cov tshuaj txo cov roj cholesterol, kev sim tshuaj tau pom tias cov tshuaj statin tuaj yeem txhim kho cov txiaj ntsig ntev ntawm cov neeg uas muaj kab mob plawv (CAD), thiab cov neeg muaj kev pheej hmoo siab los ntawm kev tsim CAD. .

Statins kuj tseem txo cov kev pheej hmoo ntawm kev mob plawv tom ntej, thiab txo qis kev pheej hmoo tuag los ntawm CAD.(Cov tshiab PCSK9 inhibitors tau tam sim no tau pom nyob rau hauv RCTs loj los txhim kho cov txiaj ntsig kho mob.)

Qhov peev xwm ntawm statins no los txhim kho cov txiaj ntsig kho mob tau zoo yog xav tias yuav tshwm sim, tsawg kawg hauv ib feem, los ntawm qee qhov lossis tag nrho lawv cov txiaj ntsig tsis yog cov roj cholesterol.Ntxiv nrog rau kev txo qis LDL cov roj cholesterol, statins kuj muaj cov tshuaj tiv thaiv kab mob, tiv thaiv cov ntshav txhaws, thiab cov plaque-stabilizing zog.Tsis tas li ntawd, cov tshuaj no txo ​​qis C-reactive protein ntau ntau, txhim kho vascular tag nrho, thiab txo txoj kev pheej hmoo ntawm kev ua rau lub plawv tsis zoo.

Nws yog qhov muaj feem ntau tias cov txiaj ntsig kho mob tau pom los ntawm cov tshuaj statin yog vim muaj kev sib xyaw ntawm lawv cov cholesterol-txo cov teebmeem thiab lawv cov kev sib txawv ntawm cov teebmeem tsis muaj roj cholesterol.

Rosuvastatin txawv li cas?

Rosuvastatin yog ib qho tshiab, hu ua "thib peb tiam" tshuaj statin.Qhov tseem ceeb, nws yog cov tshuaj muaj zog tshaj plaws statin hauv khw.

Nws cov txheeb ze lub zog muab los ntawm nws cov yam ntxwv tshuaj, uas tso cai rau nws los khi ntau ruaj khov rau HMG CoA reductase, yog li ua rau muaj kev cuam tshuam ntau dua ntawm cov enzyme no.Molecule rau molecule, rosuvastatin tsim ntau LDL-cholesterol-txo dua lwm cov tshuaj statin.Txawm li cas los xij, qhov zoo sib xws ntawm kev txo cov roj cholesterol tuaj yeem ua tiav los ntawm kev siv ntau dua ntawm lwm cov statins.

Thaum "kev kho mob hnyav" statin xav tau los thawb cov roj cholesterol kom tsawg li sai tau, rosuvastatin yog cov tshuaj mus rau ntau tus kws kho mob.

Cov txiaj ntsig ntawm Rosuvastatin

Rosuvastatin tau txais lub koob npe nrov ntawm kev ua haujlwm tshwj xeeb ntawm cov tshuaj statin, feem ntau yog los ntawm cov txiaj ntsig ntawm ob qhov kev sim tshuaj.

Xyoo 2008, kev tshaj tawm ntawm JUPITER txoj kev tshawb fawb tau txais kev saib xyuas ntawm cov kws kho plawv txhua qhov chaw.Hauv txoj kev tshawb no, ntau dua 17,000 tus neeg noj qab haus huv uas muaj cov ntshav LDL cov roj cholesterol ib txwm tab sis nce qib CRP tau randomized kom tau txais 20 mg ib hnub twg ntawm rosuvastatin lossis placebo.

Thaum ua raws li, tib neeg randomized rau rosuvastatin tsis tau tsuas yog txo qis LDL cov roj cholesterol thiab qib CRP, tab sis lawv kuj muaj tsawg dua cov xwm txheej ntawm cov hlab plawv (xws li mob plawv, mob stroke, xav tau cov txheej txheem revascularization xws li stent lossis bypass phais, thiab kev sib xyaw ua ke ntawm lub plawv nres, lossis kev tuag ntawm cov hlab plawv), nrog rau kev txo qis hauv txhua qhov kev tuag.

Txoj kev tshawb no tau zoo kawg nkaus tsis yog vim tias rosuvastatin tau txhim kho cov txiaj ntsig tau zoo hauv cov neeg noj qab haus huv, tab sis kuj vim tias cov neeg no tsis tau nce qib roj cholesterol thaum lub sijhawm sau npe.

Hauv 2016, HOPE-3 sim tau luam tawm.Txoj kev tshawb no tau tso npe ntau dua 12,000 tus neeg uas muaj tsawg kawg yog ib qho kev pheej hmoo rau cov kab mob atherosclerotic vascular, tab sis tsis muaj CAD.Cov neeg koom nrog tau randomized kom tau txais rosuvastatin lossis placebo.Thaum kawg ntawm ib lub xyoo, cov neeg noj rosuvastatin tau txo qis hauv cov txiaj ntsig ntawm qhov kawg (xws li mob plawv tsis ua hauj lwm lossis mob stroke, lossis tuag los ntawm kab mob plawv).

Hauv ob qho kev sim no, randomization rau rosuvastatin tau txhim kho cov txiaj ntsig ntawm cov neeg uas muaj ib lossis ntau qhov kev pheej hmoo, tab sis tsis muaj cov tsos mob ntawm cov kab mob plawv.

Nws yuav tsum raug sau tseg tias rosuvastatin tau raug xaiv rau cov kev sim no tsis yog vim tias nws yog qhov muaj zog tshaj plaws ntawm cov tshuaj statin, tab sis (tsawg kawg yog feem ntau) vim tias qhov kev sim no tau txhawb nqa los ntawm AstraZeneca, tus tsim ntawm rosuvastatin.

Feem ntau cov kws tshaj lij lipid ntseeg tias cov txiaj ntsig ntawm cov kev sim no yuav zoo ib yam yog tias lwm cov tshuaj statin tau siv ntawm qhov ntau npaum li cas, thiab qhov tseeb, cov lus pom zoo tam sim no ntawm kev kho nrog cov tshuaj statin feem ntau tso cai rau kev siv ib yam ntawm cov tshuaj statin ntev li ntev tau. Kev noj tshuaj ntau txaus kom ua tiav qhov sib npaug ntawm cov roj cholesterol-txo raws li yuav ua tiav nrog qis dua ntawm rosuvastatin.(Ib qho kev zam rau txoj cai dav dav no tshwm sim thaum "kev kho mob hnyav statin" raug hu rau. Intensive statin therapy yog to taub txhais tau tias yog cov koob tshuaj rosuvastatin lossis siab-dose atorvastatin, uas yog cov tshuaj statin tom ntej uas muaj zog tshaj plaws.)

Tab sis vim tias rosuvastatin yog qhov tseeb ntawm statin uas tau siv hauv ob qhov kev sim tshuaj ntsuam xyuas no, ntau tus kws kho mob tau ua txhaum cai rau kev siv rosuvastatin raws li lawv cov statin xaiv.

Cov lus qhia tam sim no

Kev kho statin yog qhia los txhim kho cov ntshav lipid txawv txav (tshwj xeeb, txo qis LDL cholesterol thiab / lossis qib triglyceride), thiab tiv thaiv kab mob plawv.Statins raug pom zoo rau cov neeg uas muaj cov kab mob atherosclerotic plawv, cov neeg mob ntshav qab zib, thiab cov neeg uas muaj kwv yees li 10 xyoo ntawm kev pheej hmoo ntawm kev mob plawv yog siab dua 7.5% mus rau 10%.

Thaum, feem ntau, cov tshuaj statin suav hais tias hloov pauv tau ntawm lawv cov txiaj ntsig thiab lawv txoj kev pheej hmoo ua rau muaj kev cuam tshuam tsis zoo, tej zaum yuav muaj qee lub sijhawm uas rosuvastatin yuav nyiam.Tshwj xeeb, thaum "kev siv siab" statin kho yog tsom txo qis LDL cov roj cholesterol kom qis tshaj plaws, xws li rosuvastatin lossis atorvastatin ntawm lawv cov koob tshuaj ntau dua tau pom zoo.

Ua ntej noj

Ua ntej koj tau txais cov tshuaj statin, koj tus kws kho mob yuav ua qhov kev ntsuam xyuas kev pheej hmoo los kwv yees koj txoj kev pheej hmoo ntawm kev mob plawv thiab yuav ntsuas koj cov ntshav lipid.Yog tias koj twb muaj kab mob plawv los yog muaj kev pheej hmoo loj heev ntawm kev tsim nws, koj tus kws kho mob yuav pom zoo kom siv tshuaj statin.

Lwm cov tshuaj statin feem ntau muaj xws li atorvastatin, simvastatin, fluvastatin, lovastatin, pitavastatin, thiab pravastatin.

Crestor, hom npe ntawm rosuvastatin nyob rau hauv Teb Chaws Asmeskas, yog kim heev, tab sis generic cov ntaub ntawv ntawm rosuvastatin tam sim no muaj.Yog tias koj tus kws kho mob xav kom koj noj rosuvastatin, nug seb koj puas siv tau.

Statins yuav tsum tsis txhob siv rau cov neeg uas tsis haum rau statins lossis ib qho ntawm lawv cov khoom xyaw, cev xeeb tub lossis pub niam mis, uas muaj kab mob siab lossis lub raum tsis ua haujlwm, lossis haus cawv ntau dhau.Cov kev tshawb fawb qhia tias rosuvastatin tuaj yeem siv tau zoo rau cov menyuam yaus hnub nyoog qis dua 10 xyoo.

Kev noj tshuaj rosuvastatin

Thaum rosuvastatin tau siv los txo qis LDL cov roj cholesterol, feem ntau qis dua yog pib (5 mus rau 10 mg ib hnub) thiab hloov kho siab dua txhua lub hlis lossis ob zaug raws li qhov tsim nyog.Hauv cov neeg mob hypercholesterolemia hauv tsev neeg, cov kws kho mob feem ntau pib nrog cov koob tshuaj ntau dua (10 mus rau 20 mg ib hnub).

Thaum rosuvastatin tau siv los txo qhov kev pheej hmoo ntawm cov kab mob plawv hauv cov neeg uas muaj kev pheej hmoo siab, qhov pib koob tshuaj feem ntau yog 5 mus rau 10 mg ib hnub twg.Hauv cov neeg uas nws qhov kev pheej hmoo raug suav tias yog siab (tshwj xeeb, lawv qhov kev pheej hmoo 10 xyoo yog kwv yees siab dua 7.5%), kev siv tshuaj siv ntau zaus pib, nrog 20 mus rau 40 mg ib hnub twg.

Yog tias rosuvastatin tau siv los txo qhov kev pheej hmoo ntawm cov kab mob plawv ntxiv hauv ib tus neeg uas twb muaj kab mob plawv, kev kho mob hnyav feem ntau yog ua haujlwm nrog koob tshuaj 20 txog 40 mg ib hnub.

Hauv cov neeg uas noj cyclosporine lossis tshuaj rau HIV / AIDS, lossis hauv cov neeg uas muaj lub raum tsis ua haujlwm, cov koob tshuaj rosuvastatin yuav tsum tau kho kom qis, thiab feem ntau yuav tsum tsis pub tshaj 10 mg ib hnub twg.

Cov neeg ntawm cov neeg Esxias qhovntsej thiaj tsis mob siab rau cov tshuaj statin thiab ua rau muaj kev phiv ntau dua.Nws feem ntau pom zoo tias rosuvastatin yuav tsum pib ntawm 5 mg ib hnub twg thiab nce ntxiv hauv cov neeg Esxias.

Rosuvastatin tau noj ib zaug ib hnub, thiab tuaj yeem noj thaum sawv ntxov lossis yav tsaus ntuj.Tsis zoo li ob peb ntawm lwm cov tshuaj statin, haus cov kua txiv kab ntxwv me me tsis zoo rau rosuvastatin.

Cov teebmeem ntawm Rosuvastatin

Nyob rau hauv lub xyoo tam sim tom qab rosuvastatin tau tsim, ntau tus kws tshaj lij tau tshaj tawm tias cov kev mob tshwm sim ntawm statin yuav txo qis nrog rosuvastatin, tsuas yog vim tias qis dua tuaj yeem siv los ua kom txo qis cov roj cholesterol.Nyob rau tib lub sijhawm, lwm tus kws tshaj lij tau lees tias cov kev mob tshwm sim ntawm statin yuav ua kom zoo dua nrog cov tshuaj no, vim tias nws muaj zog dua li lwm cov statins.

Hauv kev cuam tshuam xyoo, nws tau pom meej tias tsis muaj qhov lees paub tseeb.Nws zoo li hom thiab qhov loj ntawm cov teebmeem tshwm sim feem ntau yog tib yam nrog rosuvastatin raws li nws nrog lwm cov tshuaj statin.

Statins, raws li ib pab pawg, tau txais txiaj ntsig zoo dua li lwm cov tshuaj txo cov roj cholesterol.Hauv kev tshuaj ntsuam meta-tshaj tawm xyoo 2017 uas tau saib ntawm 22 qhov kev sim tshuaj ntsuam xyuas, tsuas yog 13.3% ntawm cov tib neeg randomized rau cov tshuaj statin txiav cov tshuaj vim muaj kev phiv nyob rau hauv 4 xyoo, piv rau 13.9% ntawm cov neeg randomized rau cov placebo.

Txawm li cas los xij, muaj cov kev mob tshwm sim zoo uas tshwm sim los ntawm cov tshuaj statin, thiab cov kev mob tshwm sim no feem ntau siv rau rosuvastatin thiab lwm yam statin.Qhov tseem ceeb tshaj plaws ntawm cov kev mob tshwm sim no muaj xws li:

• Cov leeg mob ntsig txog cov xwm txheej tsis zoo.Cov leeg nqaij toxicity tuaj yeem tshwm sim los ntawm statins.Cov tsos mob tej zaum yuav muaj xws li myalgia ( mob nqaij ), nqaij tsis muaj zog , nqaij o, los yog (nyob rau hauv tsawg, mob hnyav) rhabdomyolysls.Rhabdomyolysis yog mob raum tsis ua haujlwm los ntawm cov leeg mob hnyav.Feem ntau.Cov kev mob tshwm sim ntawm cov leeg nqaij tuaj yeem tswj tau los ntawm kev hloov mus rau lwm qhov statin.Rosuvastatin yog ib qho ntawm cov tshuaj statin uas tshwm sim ua rau cov leeg mob me me.Hauv qhov sib piv, lovastatin, simvastatin, thiab atorvastatin yog qhov ua rau muaj teeb meem ntawm cov leeg.
• Teeb meem daim siab.Kwv yees li 3% ntawm cov neeg noj statins yuav muaj kev nce siab hauv siab enzymes hauv lawv cov ntshav.Hauv feem ntau ntawm cov neeg no, tsis muaj pov thawj ntawm lub siab puas tsuaj tiag tiag, thiab qhov tseem ceeb ntawm qhov nce me me hauv cov enzymes tsis meej.Hauv ob peb tus neeg, qhov mob siab heev tau raug tshaj tawm;Nws tsis paub meej, txawm li cas los xij, qhov xwm txheej ntawm lub siab mob hnyav yog siab dua hauv cov neeg noj statins ntau dua li cov pej xeem.Tsis muaj qhov qhia tau tias rosuvastatin ua rau muaj teeb meem siab dua lossis tsawg dua li lwm cov statins.
• Kev paub tsis meej.Cov kev xav tias statins tuaj yeem ua rau muaj kev xav tsis zoo, nco tsis tau, kev nyuaj siab, kev chim siab, kev ua phem, lossis lwm yam kev cuam tshuam hauv nruab nrab ntawm lub paj hlwb tau raug tsa, tab sis tsis tau pom meej meej.Hauv kev tshuaj xyuas ntawm cov ntaub ntawv ceeb toom xa mus rau FDA, cov teeb meem kev paub txog kev paub nrog statins tshwm sim ntau dua nrog cov tshuaj lipophilic statin, suav nrog atorvastatin, fluvastatin, lovastatin, thiab simvastatin.Cov tshuaj hydrophilic statin, suav nrog rosuvastatin, tau cuam tshuam tsawg dua nrog qhov tshwm sim tsis zoo no.
• Mob ntshav qab zib.Nyob rau hauv xyoo tas los no, me me ntawm kev txhim kho ntshav qab zib tau cuam tshuam nrog kev kho statin.Ib xyoo 2011 meta-kev tshuaj xyuas ntawm tsib qhov kev sim tshuaj ntsuam xyuas qhia tias ib kis ntxiv ntawm ntshav qab zib tshwm sim hauv txhua 500 tus neeg kho nrog cov tshuaj statins siab.Feem ntau, qhov kev pheej hmoo ntawm qhov kev pheej hmoo no suav hais tias yog qhov tsim nyog tau ntev npaum li cov statin tuaj yeem xav tias yuav txo qis tag nrho cov kev pheej hmoo plawv.

Lwm cov kev mob tshwm sim uas tau tshaj tawm nrog cov tshuaj statin suav nrog xeev siab, raws plab, thiab mob pob qij txha.

Kev sib tham

Kev noj qee yam tshuaj tuaj yeem ua rau muaj kev pheej hmoo ntawm kev mob tshwm sim nrog rosuvastatin (lossis ib qho statin).Cov npe no yog qhov ntev, tab sis cov tshuaj tseem ceeb tshaj plaws uas cuam tshuam nrog rosuvastatin suav nrog:

• Gemfibrozil, uas yog ib qho uas tsis yog-statin-txo cov cholesterol
• Amiodarone, uas yog ib qho tshuaj tiv thaiv arrhythmic
• Muaj cov tshuaj HIV
• Qee cov tshuaj tua kab mob, tshwj xeeb yog clarithromycin thiab itraconazone
• Cyclosporine, tshuaj tiv thaiv kab mob

Ib Lo Lus Los ntawm Verywell

Thaum rosuvastatin yog qhov muaj zog tshaj plaws statin muaj, feem ntau, nws cov txiaj ntsig thiab cov tshuaj lom neeg muaj txiaj ntsig zoo ib yam li tag nrho lwm cov statins.Tseem, muaj qee qhov xwm txheej kho mob uas rosuvastatin yuav nyiam dua lwm cov tshuaj statin.