Tuam Tshoj Pomalidomide tuam ntxhab thiab cov muag khoom

Pomalidomide

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API lub npe	Qhov taw qhia	Innovator	Patent Expiry Date (Tebchaws Asmeskas)
Pomalidomide	Oncology tshuaj	Celgene

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Pomalidomide, yav tas los hu ua CC-4047 los yog actimid, yog ib lub zog immunomodulatory molecule uas nthuav tawm cov haujlwm antineoplastic rau kev kho mob hematological malignancies, tshwj xeeb tshaj yog rov qab thiab refractory ntau myeloma (MM). Raws li ib tug derivative ntawm thalidomide, pomalidomide muaj ib tug zoo xws li cov qauv tshuaj raws li thalidomide tsuas yog ntxiv ntawm ob pawg oxo nyob rau hauv lub phthaloyl nplhaib thiab ib tug amino pawg ntawm plaub txoj hauj lwm. Feem ntau, raws li ib qho immunomodulatory molecule, pomalidomide qhia antitumor kev ua los ntawm ib tug mechanism ntawm thaiv cov qog microenvironment los ntawm kev hloov kho ntawm cov qog-txhawb cytokines (TNF-α, IL-6, IL-8 thiab VEGF), ncaj qha down-regulating tseem ceeb functions ntawm qog. cell, thiab koom nrog kev txhawb nqa los ntawm cov kab mob uas tsis muaj zog tiv thaiv kab mob.

Pomalidomide yog siv los kho ntau yam myeloma (mob qog noj ntshav los ntawm cov kab mob ntshav siab). Pomalidomide feem ntau yog muab tom qab tsawg kawg ob yam tshuaj tau sim tsis ua tiav.

Pomalidomide kuj tseem siv los kho AIDS ntsig txog Kaposi sarcoma thaum lwm cov tshuaj tsis ua haujlwm lossis tsis ua haujlwm. pomalidomide tuaj yeem siv los kho Kaposi Sarcoma hauv cov neeg lausHIV- tsis zoo.

Pomalidomide tsuas yog muaj los ntawm lub tsev muag tshuaj muaj ntawv pov thawj raws li qhov kev pabcuam tshwj xeeb. Koj yuav tsum tau sau npe rau hauv qhov program thiab pom zoo sivtswj kev yug me nyuamntsuas raws li qhov xav tau.

Pomalidomide kuj tseem siv tau rau cov hom phiaj tsis tau teev tseg hauv phau ntawv qhia tshuaj no.

Pomalidomide tuaj yeem ua rau mob hnyav, ua rau muaj kev phom sij rau lub neej lossis kev tuag ntawm tus menyuam yog leej niam lossis leej txiv tau noj pomalidomide thaum lub sijhawm xeeb tub lossis thaum cev xeeb tub. Txawm tias ib koob tshuaj pomalidomide tuaj yeem ua rau tus menyuam mos ob txhais caj npab thiab txhais ceg, pob txha, pob ntseg, qhov muag, ntsej muag, thiab lub plawv. Tsis txhob siv pomalidomide yog tias koj cev xeeb tub. Qhia rau koj tus kws kho mob tam sim ntawd yog tias koj lub caij nyoog qeeb thaum noj pomalidomide.