Relugolix yog siv los kho mob qog noj ntshav hauv cov txiv neej.
Hom Lub Npe: Orgovyx
Chav Kawm Tshuaj: Antineoplastic - LHRH (GnRH) Antagonist Pituitary Suppressants
Muaj: Yuav tsum tau muab tshuaj
Cev xeeb tub: Nrog koj tus kws kho mob tham. Cov tshuaj no yuav ua rau muaj teeb meem rau tus menyuam hauv plab.
Lactation: Tham nrog kws kho mob ua ntej siv

Relugolix yog ib qho kev hais lus muaj, uas tsis yog peptide gonadotropin-tso tshuaj hormone (GnRH lossis luteinizing hormone-releasing hormone (LHRH)) antagonist, muaj peev xwm ua haujlwm antineoplastic. Relugolix sib tw khi rau thiab thaiv GnRH receptor nyob rau hauv lub caj pas anterior pituitary, uas ob leeg tiv thaiv GnRH khi rau GnRH receptor thiab inhibits qhov tso tawm thiab tso tawm ntawm ob qho tib si luteinizing hormone (LH) thiab follicle stimulating hormone (FSH). Hauv cov txiv neej, qhov inhibition ntawm LH secretion tiv thaiv kev tso tawm ntawm testosterone los ntawm Leydig hlwb hauv cov noob qes. Txij li thaum testosterone yuav tsum tau txhawb nqa kev loj hlob ntawm prostate, txo qis testosterone qib tuaj yeem cuam tshuam cov tshuaj hormone-dependant prostate cancer cell proliferation.

Relugolix yog gonadotropin-tso cov tshuaj hormones (GnRH) receptor antagonist siv los kho ntau yam tshuaj tiv thaiv kab mob. Nws tau pom zoo thawj zaug hauv Nyij Pooj xyoo 2019, raws li lub npe Relumina, rau cov tsos mob ntawm kev kho mob uterine fibroids, thiab tsis ntev los no los ntawm Teb Chaws Asmeskas 'FDA xyoo 2020, nyob rau hauv lub npe hom Orgovyx, rau kev kho mob ntawm prostate cancer siab heev. Relugolix kuj tau kawm nyob rau hauv cov tsos mob ntawm endometriosis. Relugolix yog thawj zaug (thiab tam sim no nkaus xwb) qhov ncauj-tswj GnRH receptor antagonist pom zoo rau kev kho mob qog noj ntshav prostate - cov kev kho mob zoo sib xws xws li [degarelix] xav tau kev tswj hwm subcutaneous - thiab yog li muab cov kev xaiv kho mob tsawg dua rau cov neeg mob uas yuav txwv tsis pub mus ntsib kws kho mob. rau kev tswj hwm los ntawm cov kws kho mob. Ntxiv rau nws cov txheeb ze yooj yim-ntawm-siv, relugolix tau pom tias ua tau zoo dua hauv kev nyuaj siab ntawm testosterone qib thaum piv rau [leuprolide], lwm txoj kev kho mob androgen deprivation siv hauv kev kho mob qog noj ntshav prostate.

Relugolix yog Gonadotropin Releasing Hormone Receptor Antagonist. Lub mechanism ntawm kev txiav txim ntawm relugolix yog raws li ib tug Gonadotropin Releasing Hormone Receptor Antagonist, thiab Cytochrome P450 3A Inducer, thiab Cytochrome P450 2B6 Inducer, thiab Cancer Cancer Resistance Protein Inhibitor, thiab P-Glycoprotein Inhibitor. Cov nyhuv physiologic ntawm relugolix yog los ntawm kev txo qis GnRH Secretion.

Cov qauv tshuaj