Bictegravir 1611493-60-7
Kev piav qhia
Bictegravir yog ib qho tshiab, muaj zog inhibitor ntawm HIV-1 integrase nrog IC50 ntawm 7.5 nM.
Hauv Vitro
Bictegravir (BIC) inhibits strand hloov kev ua haujlwm nrog IC50 ntawm 7.5± 0,3nm ua.txheeb ze rau nws inhibition ntawm strand hloov kev ua ub no, Bictegravir yog ib tug ntau zog inhibitor ntawm 3'-kev ua haujlwm ntawm HIV-1 IN, nrog IC50 ntawm 241±51n hmo.Bictegravir txhim kho qhov tsub zuj zuj ntawm 2-LTR lub voj voog ~ 5-fold txheeb ze rau kev tswj hwm kev kho mob thiab txo cov nqi ntawm cov khoom sib xyaw ua ke hauv cov kab mob kis los ntawm 100-fold.Bictegravir muaj zog inhibits HIV-1 replication nyob rau hauv ob qho tib si MT-2 thiab MT-4 hlwb nrog EC50s ntawm 1.5 thiab 2.4 nM, feem.Bictegravir nthuav tawm cov tshuaj tua kab mob muaj zog hauv thawj CD4 + T lymphocytes thiab monocyte-derived macrophages, nrog EC50s ntawm 1.5.±0.3nM thiab 6.6±4.1 nM, feem, uas yog piv rau cov txiaj ntsig tau txais hauv T-cell kab[1].
MCE tsis tau lees paub qhov tseeb ntawm cov txheej txheem no.Lawv yog rau siv xwb.
NCT Num | Txhawb nqa | Qhov xwm txheej | Pib Hnub | Theem |
NCT03998176 | University of Nebraska | Gilead Sciences | HIV-1- kab mob | Kaum Hli 9, 2019 | Theem 4 |
NCT03789968 | Thomas Jefferson University | University of Maryland, College Park | Indiana University Health | Tsev Kho Mob Brooklyn Tsev Kho Mob | University of Illinois ntawm Chicago | Nova Southeastern University | University of California, San Francisco | HIV + AIDS | Cuaj hlis 1, 2019 | |
NCT04249037 | University of Colorado, Denver | Gilead Sciences | HIV + AIDS | Lub Peb Hlis 1, 2020 | Tsis siv tau |
NCT04132674 | Vancouver Infectious Diseases Center | Human Immunodeficiency Virus I Infection | Kev Siv Tshuaj | Kaum Ib Hlis 26, 2018 | Theem 4 |
NCT04054089 | Cristina Mussini | University of Modena thiab Reggio Emilia | Kab mob HIV | Cuaj hlis 2019 | Theem 4 |
NCT04155554 | Azienda Ospedaliera Universitaria Senese|Catholic University of the Sacred Heart|Ospedale Policlinico San Martino|Azienda Ospedaliera San Paolo|Ospedale Amedeo di Savoia | HIV-1- kab mob | Lub Ib Hlis 29, 2020 | Theem 3 |
NCT02275065 | Gilead Sciences | Kab mob HIV-1 | Lub Kaum Hli 2014 | Theem 1 |
NCT03711253 | University of Southern California | Tus kab mob HIV | Kaum Hli 14, 2019 | Theem 4 |
NCT02400307 | Gilead Sciences | HIV | Plaub Hlis Ntuj 17, 2015 | Theem 1 |
NCT03499483 | Fenway Community Health | Kev Tiv Thaiv HIV | Lub Ib Hlis 24, 2019 | Theem 4 |
NCT03502005 | Midland Research Group, Inc.|Gilead Sciences | Human Immunodeficiency Virus | Lub Peb Hlis 1, 2018 | Theem 4 |
Cov qauv tshuaj
Tswv yim18Quality Consistency Evaluation tej yaam num uas tau pom zoo4, thiab6tej yaam num raug tso cai.
Advanced thoob ntiaj teb kev tswj hwm qhov system tau tso lub hauv paus ruaj khov rau kev muag khoom.
Kev saib xyuas zoo ua haujlwm los ntawm tag nrho lub neej voj voog ntawm cov khoom kom ntseeg tau tias qhov zoo thiab kho cov nyhuv.
Pab Pawg Kev Tswj Xyuas Kev Tswj Xyuas Kev Ua Haujlwm txhawb nqa qhov kev xav tau zoo thaum lub sijhawm thov thiab tso npe.