Tuam Tshoj Bictegravir 1611493-60-7 manufacturers thiab lwm |CPF

Bictegravir 1611493-60-7

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API lub npe	Qhov taw qhia	Innovator	Patent Expiry Date (Tebchaws Asmeskas)
Bictegravir 1611493-60-7	Tus kab mob HIV-1	Gilead Sciences	Kaum Ob Hlis 19, 2033

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Bictegravir yog ib qho tshiab, muaj zog inhibitor ntawm HIV-1 integrase nrog IC50 ntawm 7.5 nM.

Hauv Vitro

Bictegravir (BIC) inhibits strand hloov kev ua haujlwm nrog IC50 ntawm 7.5± 0,3nm ua.txheeb ze rau nws inhibition ntawm strand hloov kev ua ub no, Bictegravir yog ib tug ntau zog inhibitor ntawm 3'-kev ua haujlwm ntawm HIV-1 IN, nrog IC50 ntawm 241±51n hmo.Bictegravir txhim kho qhov tsub zuj zuj ntawm 2-LTR lub voj voog ~ 5-fold txheeb ze rau kev tswj hwm kev kho mob thiab txo cov nqi ntawm cov khoom sib xyaw ua ke hauv cov kab mob kis los ntawm 100-fold.Bictegravir muaj zog inhibits HIV-1 replication nyob rau hauv ob qho tib si MT-2 thiab MT-4 hlwb nrog EC50s ntawm 1.5 thiab 2.4 nM, feem.Bictegravir nthuav tawm cov tshuaj tua kab mob muaj zog hauv thawj CD4 + T lymphocytes thiab monocyte-derived macrophages, nrog EC50s ntawm 1.5.±0.3nM thiab 6.6±4.1 nM, feem, uas yog piv rau cov txiaj ntsig tau txais hauv T-cell kab[1].

MCE tsis tau lees paub qhov tseeb ntawm cov txheej txheem no.Lawv yog rau siv xwb.

NCT Num	Txhawb nqa	Qhov xwm txheej	Pib Hnub	Theem
NCT03998176	University of Nebraska \| Gilead Sciences	HIV-1- kab mob	Kaum Hli 9, 2019	Theem 4
NCT03789968	Thomas Jefferson University \| University of Maryland, College Park \| Indiana University Health \| Tsev Kho Mob Brooklyn Tsev Kho Mob \| University of Illinois ntawm Chicago \| Nova Southeastern University \| University of California, San Francisco	HIV + AIDS	Cuaj hlis 1, 2019
NCT04249037	University of Colorado, Denver \| Gilead Sciences	HIV + AIDS	Lub Peb Hlis 1, 2020	Tsis siv tau
NCT04132674	Vancouver Infectious Diseases Center	Human Immunodeficiency Virus I Infection \| Kev Siv Tshuaj	Kaum Ib Hlis 26, 2018	Theem 4
NCT04054089	Cristina Mussini \| University of Modena thiab Reggio Emilia	Kab mob HIV	Cuaj hlis 2019	Theem 4
NCT04155554	Azienda Ospedaliera Universitaria Senese\|Catholic University of the Sacred Heart\|Ospedale Policlinico San Martino\|Azienda Ospedaliera San Paolo\|Ospedale Amedeo di Savoia	HIV-1- kab mob	Lub Ib Hlis 29, 2020	Theem 3
NCT02275065	Gilead Sciences	Kab mob HIV-1	Lub Kaum Hli 2014	Theem 1
NCT03711253	University of Southern California	Tus kab mob HIV	Kaum Hli 14, 2019	Theem 4
NCT02400307	Gilead Sciences	HIV	Plaub Hlis Ntuj 17, 2015	Theem 1
NCT03499483	Fenway Community Health	Kev Tiv Thaiv HIV	Lub Ib Hlis 24, 2019	Theem 4
NCT03502005	Midland Research Group, Inc.\|Gilead Sciences	Human Immunodeficiency Virus	Lub Peb Hlis 1, 2018	Theem 4