Captopril
Kev piav qhia
Captopril (SQ-14534) yog lub zog, kev sib tw inhibitor ntawm angiotensin-hloov enzyme (ACE).
Hauv Vitro
Captopril (SQ-14534) tau pom tias muaj cov txiaj ntsig zoo sib xws thiab kev tuag rau cov tshuaj diuretics thiab beta-blockers hauv cov neeg mob ntshav siab. Captopril (SQ-14534) tau pom tias ncua kev loj hlob ntawm cov ntshav qab zib nephropathy, thiab enalapril thiab lisinopril tiv thaiv kev txhim kho nephropathy hauv cov neeg mob ntshav qab zib normoalbuminuric[1]. Ib qho piv txwv ntawm cis thiab trans xeev ntawm Captopril (SQ-14534) muaj nyob rau hauv cov kev daws teeb meem thiab cov enzyme xaiv tsuas yog lub xeev ntawm cov inhibitor uas nthuav tawm architectural thiab stereoelectronic complementarity nrog nws cov substrate binding groove [2].
MCE tsis tau lees paub qhov tseeb ntawm cov txheej txheem no. Lawv yog rau siv xwb.
Kev sim tshuaj
| NCT Num | Txhawb nqa | Qhov xwm txheej | Pib Hnub | Theem |
| NCT03179163 | Penn State University | Lub Tebchaws Lub Plawv, Lub ntsws, thiab Ntshav Lub Tsev Haujlwm (NHLBI) | Ntshav siab, Qhov tseem ceeb | Lub Xya hli ntuj 20, 2016 | Phase 1 | Phase 2 |
| NCT03660293 | Tanta University | Mob ntshav qab zib mellitus, hom 1 | Plaub Hlis Ntuj 1, 2017 | Tsis siv tau |
| NCT03147092 | Centro Neurológico de Pesquisa thiab Reabiitação, Brazil | Ntshav siab | Ntshav siab | Lub Ob Hlis 1, 2018 | Thaum Ntxov Theem 1 |
| NCT00252317 | Rigshospitalet, Denmark | Aortic Stenosis | Kaum Ib Hlis 2005 | Theem 4 |
| NCT02217852 | West China Hospital | Ntshav siab | Lub yim hli ntuj 2014 | Theem 4 |
| NCT01626469 | Brigham thiab Women's Hospital | Hom 2 Mob ntshav qab zib mellitus | Tsib Hlis 2012 | Phase 1 | Phase 2 |
| NCT00391846 | AstraZeneca | Lub plawv Failure | Ventricular Dysfunction, Sab laug | Lub Kaum Hli 2006 | Theem 4 |
| NCT00240656 | Hebei Medical University | Ntshav siab, Pulmonary | Lub Kaum Hli 2005 | Theem 1 |
| NCT00086723 | Northwestern University | National Cancer Institute (NCI) | Unspecified Adult Solid Tumor, Protocol Specific | Lub Xya Hli 2003 | Phase 1 | Phase 2 |
| NCT00663949 | Shiraz University of Medical Sciences | Mob ntshav qab zib nephropathy | Lub Ob Hlis 2006 | Phase 2 | Phase 3 |
| NCT01437371 | Tsev Kho Mob Tsev Kho Mob, Clermont-Ferrand|Servier|LivaNova | Lub plawv tsis ua hauj lwm | Lub yim hli ntuj 2011 | Theem 3 |
| NCT04288700 | Ain Shams University | Infantile Hemangioma | Kaum Hli 1, 2019 | Theem 4 |
| NCT00223717 | Vanderbilt University | Vanderbilt University Medical Center | Ntshav siab | Lub Ib Hlis 2001 | Theem 1 |
| NCT02770378 | Tsev kawm ntawv ntawm Ulm | Kev Kho Mob Cancer Reliable | Anticancer Fund, Belgium | Glioblastoma | Kaum Ib Hlis 2016 | Phase 1 | Phase 2 |
| NCT01761916 | Instituto Materno Infantil Prof. Fernando Figueira | Preeclampsia | Lub Ib Hlis 2013 | Theem 4 |
| NCT01545479 | Instituto de Cardiologia do Rio Grande do Sul | Mob raum | Lub Ib Hlis 2010 | Theem 4 |
| NCT00935805 | Tsev Kho Mob de Clinicas de Porto Alegre | Conselho Nacional de Desenvolvimento Científico e Tecnológico | Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul, Brazil | Mob ntshav qab zib mellitus | Arterial Hypertension | Lub Xya Hli 2006 |
|
| NCT00742040 | Tsev Kho Mob rau Cov Me Nyuam Mob | Mob plawv | Lub yim hli ntuj 2008 | Theem 2 |
| NCT03613506 | Wuhan University | Kev Kho Mob Sab Nraud | Noj Captopril | Lub Kaum Hli 25, 2018 | Theem 2 |
| NCT00004230 | Northwestern University | National Cancer Institute (NCI) | Mob qog noj ntshav | Lub Kaum Hli 1999 | Theem 3 |
| NCT00660309 | Novartis | Hom 2 Mob ntshav qab zib mellitus | Plaub Hlis Ntuj 2008 | Theem 4 |
| NCT00292162 | NHS Greater Glasgow thiab Clyde | Chronic Heart Failure | Atrial Fibrillation | Lub Ib Hlis 2007 | Tsis siv tau |
| NCT01271478 | Coordinación de Investigación en Salud, Mexico | Inflammation | End-stage Renal Disease | Lub yim hli ntuj 2009 | Theem 4 |
| NCT04193137 | Chongqing Medical University | Thawj Aldosteronism | Kaum Ib Hlis 30, 2019 |
|
| NCT00155064 | National Taiwan University Tsev Kho Mob | Hyperaldosteronism | Lub Xya Hli 2002 | Theem 4 |
| NCT01292694 | Vanderbilt University | Vanderbilt University Medical Center | Mob ntshav siab | Pure Autonomic Failure | Ntau Qhov System Atrophy | Peb Hlis 2011 | Theem 1 |
| NCT00917345 | National Taiwan University Tsev Kho Mob | Novartis | Thawj Aldosteronism | Lub Ib Hlis 2008 |
|
| NCT00077064 | Radiation Therapy Oncology Group|National Cancer Institute (NCI)|NRG Oncology | Mob ntsws Cancer | Pulmonary Complications | Radiation Fibrosis | Lub Rau Hli 2003 | Theem 2 |
Cia
| Hmoov | -20 ° C | 3 xyoo |
| 4 ° C | 2 xyoo | |
| Hauv cov kuab tshuaj | -80 ° C | 6 hli |
| -20 ° C | 1 hli |
Cov qauv tshuaj
Tswv yim18Quality Consistency Evaluation tej yaam num uas tau pom zoo4, thiab6tej yaam num raug tso cai.
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