Daclatasvir Dihydrochloride
Kev piav qhia
Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) yog ib qho muaj zog thiab ua haujlwm ntawm qhov ncauj.HCV NS5A proteininhibitor nrogEC50s ntau ntawm 9-146 pM rauntau HCV relicon genotypes.Daclatasvir dihydrochloride kuj yog ib tugOrganic anion thauj polypeptide 1B (OATP1B)thiabOATP1B3inhibitor nrogIC50s ntawm 1.5 µM thiab 3.27 µM, feem.
IC50& Lub hom phiaj
EC50: 50 pM (HCV relicon genotype 1a), 9 pM (HCV relicon genotype 1b), 71 pM (HCV relicon genotype 2a), 146 pM (HCV relicon genotype 3a), 12 pM (HCV relicon genotype 3a) thiab hom 3 HCV replicon genotype 5a)[1]
Kd: 8 nM (NS5A33-202) thiab 210 nM (NS5A26-202)[2]
IC50: 1.5 µM (OATP1B) thiab 3.27 µM (OATP1B3)[3]
Hauv Vitro
Daclatasvir (BMS-790052) qhia tau tias muaj zog inhibitory kev ua haujlwm ntawm txhua tus genotypes kuaj, nrog EC50Cov nqi sib txawv ntawm 9 teev tsaus ntuj txog 146 teev tsaus ntuj.Daclatasvir inhibits HCV relicon genotype 1a, 1b, 2a, 3a, 4a thiab 5a nrog EC50Tus nqi ntawm 50 pM, 9 pM, 71 pM, 146 pM, 12 pM thiab 33 pM, feem.Daclatasvir yog ib tug muaj zog inhibitor ntawm JFH-1 genotype 2a kis tus kab mob uas replicates nyob rau hauv cell kab lis kev cai (EC50= 28 p.m.)[1].Daclatasvir (BMS-790052) khi nruj rau NS5A33-202 thiab NS5A26-202 nrog Kds ntawm 8 nM thiab 210 nM, feem[2].
Cia
| Hmoov | -20 ° C | 3 xyoo |
| 4 ° C | 2 xyoo | |
| Hauv cov kuab tshuaj | -80 ° C | 6 hli |
| -20 ° C | 1 hli |
Kev sim tshuaj
| NCT Num | Txhawb nqa | Qhov xwm txheej | Pib Hnub | Theem |
| NCT03369327 | Tehran University of Medical Sciences | RojanPharma Pharmaceutical Company | Kab mob siab C kab mob, teb rau kev kho ntawm | Tib neeg Immunodeficiency Virus | Lub Ib Hlis 1, 2017 | Theem 3 |
| NCT03485846 | R-Pharm | Almedis | Chronic Hepatitis C Genotype 1b | Kaum Ib Hlis 27, 2017 | Theem 2 |
| NCT01016912 | Bristol-Myers Squibb | Kab mob siab C | Kaum Ob Hlis 2009 | Theem 2 |
| NCT01629732 | Bristol-Myers Squibb | Kab mob siab C | Peb Hlis 2013 | Theem 2 |
| NCT01497834 | Bristol-Myers Squibb | Kab mob siab C | Lub Ib Hlis 2012 | Theem 3 |
| NCT01973049 | Bristol-Myers Squibb | Kab mob siab C | Kaum Ob Hlis 2013 | Theem 3 |
| NCT00663208 | Bristol-Myers Squibb | Kab mob siab C | Tsib Hlis 2008 | Theem 2 |
| NCT02576314 | Humanity thiab Health Research Center|Beijing 302 Tsev Kho Mob | Kab mob siab C ntev | Tsib Hlis 2015 | Theem 3 |
| NCT02756936 | Lub Chaw Tshawb Fawb Tseeb, Egypt | Zeta Pharma Pharmaceutical Industries | Noj qab nyob zoo | Lub Ob Hlis 2016 | Theem 1 |
| NCT02771405 | National Hepatology & Tropical Medicine Research Institute | Cairo University | Kab mob siab C, Chronic|Hepatocellular Carcinoma | Peb Hlis 2016 | Theem 3 |
| NCT03706898 | Viriom | HIV-1- kis kab mob | Kab mob siab | Kaum Hli 1, 2018 | Theem 1 |
| NCT02319031 | Bristol-Myers Squibb | Kab mob siab C | Lub Ob Hlis 2015 | Theem 3 |
| NCT02124044 | National Institutes of Health Clinical Center (CC)|National Institute of Allergy and Infectious Diseases (NIAID)|Bristol-Myers Squibb | HIV-HCV | Lub Ob Hlis 2014 | Theem 2 |
| NCT02551861 | Bristol-Myers Squibb | Kab mob siab C | Kaum Ob Hlis 2015 | Theem 2 |
| NCT00859053 | Bristol-Myers Squibb | Hepatic Insufficiency | Peb Hlis 2009 | Theem 1 |
| NCT01257204 | Bristol-Myers Squibb | Kab mob siab C | Kaum Ob Hlis 2010 | Theem 2 |
| NCT03063879 | Tehran University of Medical Sciences | Ahvaz Jundishapur University of Medical Sciences | Shiraz University of Medical Sciences | Hamadan University of Medical Science | Kab mob siab C, Chronic | Chronic Renal Failure | Plaub Hlis 1, 2017 | Theem 4 |
| NCT01017575 | Bristol-Myers Squibb | Kab mob siab C | Kaum Ob Hlis 2009 | Theem 2 |
| NCT02865369 | Sang Gyune Kim | Seoul National University Boramae Tsev Kho Mob | Tsev Kho Mob Severance | Inha University Tsev Kho Mob | Kauslim University | Gachon University Gil Medical Center | Hanyang University Seoul Tsev Kho Mob | Ewha Womans University Mokdong Tsev Kho Mob | Bristol-Myers Squibb | Soonchunhyang University Tsev Kho Mob | Kab mob siab C | Cuaj hlis 2016 |
|
| NCT04070235 | Nanjing Sanhome Pharmaceutical Co., Ltd. | Kab mob siab C, Chronic | Lub Peb Hlis 29, 2019 | Phase 2 | Phase 3 |
| NCT03487848 | Bristol-Myers Squibb | Kab mob siab C | Kab mob siab ntev | Lub Tsib Hlis 18, 2018 | Theem 2 |
| NCT00904059 | Bristol-Myers Squibb | Kab mob siab C | Tsib Hlis 2009 | Theem 1 |
| NCT02107365 | Fab Kis Lub Tsev Haujlwm Saib Xyuas Kev Noj Qab Haus Huv thiab Kev Tshawb Fawb Kev Kho Mob-French National Agency rau Kev Tshawb Fawb Txog AIDS thiab Viral Hepatitis (Inserm-ANRS) | Bristol-Myers Squibb | Kab mob siab C Virus Genotype 4 Infection | Kaum Ib Hlis 2013 | Theem 2 |
| NCT02397395 | Janssen R&D Ireland | Lub raum Impairment| End-stage Renal Disease | Tsib Hlis 2015 | Theem 2 |
| NCT03169348 | Assiut University | Kab mob siab C | Kaum Ib Hlis 1, 2017 | Tsis siv tau |
| NCT02323594 | Bristol-Myers Squibb | Kab mob siab C | Kaum Ob Hlis 2014 | Theem 1 |
| NCT03537196 | Fab Kis Lub Tsev Haujlwm Saib Xyuas Kev Noj Qab Haus Huv thiab Kev Tshawb Fawb Txog Kev Kho Mob-French National Agency for Research on AIDS thiab Viral Hepatitis (Inserm-ANRS) | Kab mob siab C | Kev Siv Tshuaj | Viral Hepatitis C | Kaum Ib Hlis 13, 2018 | Theem 4 |
| NCT02103569 | Bristol-Myers Squibb | Kab mob siab C | Plaub Hlis Ntuj 2014 | Theem 1 |
| NCT02772744 | Zagazig University | Cairo University | Kab mob siab C | Kaum Ib Hlis 1, 2017 |
|
| NCT01718158 | Bristol-Myers Squibb | Kab mob siab C | Lub Ib Hlis 2013 | Theem 3 |
| NCT02496078 | Bristol-Myers Squibb | Kab mob siab C | Lub yim hli ntuj 2015 | Theem 3 |
| NCT01425970 | Bristol-Myers Squibb | Kab mob siab C | Tsib Hlis 2012 | Theem 2 |
| NCT01471574 | Bristol-Myers Squibb | Kab mob siab C, Genotype 1 | Lub Kaum Ob Hlis 2011 | Theem 3 |
| NCT01573351 | Bristol-Myers Squibb | Kab mob siab C | Tsib Hlis 2012 | Theem 3 |
| NCT01938625 | Janssen R&D Ireland | Kab mob siab C, Chronic | Kaum Ob Hlis 12, 2013 | Theem 2 |
| NCT01492426 | Bristol-Myers Squibb | Kab mob siab C | Lub Ib Hlis 2012 | Theem 3 |
| NCT03480932 | Johns Hopkins Bloomberg Tsev Kawm Ntawv Kev Noj Qab Haus Huv Hauv Tebchaws | Lub Tsev Haujlwm Hauv Tebchaws ntawm Kev Siv Tshuaj Yeeb (NIDA) | YR Gaitonde Center rau Kev Tshawb Fawb thiab Kev Kawm AIDS | Kab mob siab C, Chronic | Lub Ob Hlis 2, 2018 | Phase 2 | Phase 3 |
| NCT03163849 | Assiut University | Kab mob siab ntev c | Cuaj hlis 1, 2019 | Theem 3 |
| NCT01581203 | Bristol-Myers Squibb | Kab mob siab C | Tsib Hlis 2012 | Theem 3 |
| NCT01492504 | Bristol-Myers Squibb | Kab mob siab C | Lub Ob Hlis 7, 2012 |
|
| NCT03686722 | Mohamed Raslan | Ain Shams University | Drug Research Center, Cairo, Egypt | Mob ntshav qab zib mellitus, Hom 2 | Kab mob siab C | Kev sib tham nrog tshuaj | Cuaj hlis 9, 2017 | Theem 1 |
| NCT02262728 | Janssen Kev Tshawb Fawb & Kev Txhim Kho, LLC | Kab mob siab C, Chronic | Cuaj hlis 30, 2014 | Theem 2 |
| NCT02349048 | Janssen Kev Tshawb Fawb & Kev Txhim Kho, LLC | Kab mob siab C | Lub Ib Hlis 2015 | Theem 2 |
| NCT03882307 | Assiut University | Kab mob siab C, Chronic | Tsib Hlis 2020 | Thaum Ntxov Theem 1 |
| NCT02758509 | Parc de Salut Mar | Chronic Hepatitis C | Cirrhosis | Lub Ib Hlis 1, 2010 |
|
| NCT01795911 | Bristol-Myers Squibb | Kab mob siab C | Peb Hlis 2013 | Theem 2 |
| NCT03549832 | Assiut University | Sohag University | South Valley University | HCV Coinfection | Lub Ib Hlis 1, 2018 | Tsis siv tau |
| NCT02161939 | Bristol-Myers Squibb | Kab mob siab C |
| |
| NCT01309932 | Bristol-Myers Squibb | Kab mob siab C | Peb Hlis 2011 | Theem 2 |
| NCT01995266 | Bristol-Myers Squibb | Kab mob siab C | Lub Ob Hlis 28, 2014 | Theem 3 |
| NCT02640157 | AbVie | Chronic Hepatitis C | Kab mob siab C Virus | Genotype 3 Hepatitis C Virus | Kaum Ob Hlis 2015 | Theem 3 |
| NCT02032875 | Bristol-Myers Squibb | Kab mob siab C | Peb Hlis 2014 | Theem 3 |
| NCT02624063 | Federal University of São Paulo | Kab mob siab C, Chronic | Kaum Ob Hlis 2015 | Theem 4 |
| NCT00546715 | Bristol-Myers Squibb | Kab mob siab C | Kaum Ib Hlis 2007 | Phase 1 | Phase 2 |
| NCT01718145 | Bristol-Myers Squibb | Kab mob siab C | Kaum Ib Hlis 2012 | Theem 3 |
| NCT01616524 | Bristol-Myers Squibb | Tus kab mob siab C (HCV) | Lub Xya Hli 2012 | Theem 3 |
| NCT02032901 | Bristol-Myers Squibb | Kab mob siab C | Lub Ib Hlis 2014 | Theem 3 |
| NCT03540212 | Ain Shams University | Cov kab mob HCV | Kaum Ob Hlis 10, 2017 | Phase 2 | Phase 3 |
| NCT02097966 | Bristol-Myers Squibb | Kab mob siab C |
| |
| NCT02596880 | Tehran University of Medical Sciences | Kab mob siab C | Cirrhosis | Cuaj hlis 2015 | Theem 3 |
| NCT04019717 | Atea Pharmaceuticals, Inc. | Kab mob siab C | Kab mob siab C, mob ntev | Kab mob siab C ntev | Kab mob siab C Kab mob siab | Kab mob HCV | Lub Rau Hli 20, 2019 | Theem 2 |
| NCT02992457 | Tanta University | Kab mob siab C | Lub Ib Hlis 2015 | Theem 4 |
| NCT03547895 | Zagazig University | Decompensated Cirrhosis | Lub Rau Hli 1, 2015 | Tsis siv tau |
| NCT03004625 | Kaohsiung Medical University Chung-Ho Memorial Tsev Kho Mob | Chang Gung Memorial Tsev Kho Mob | National Taiwan University Tsev Kho Mob | Taipei Veterans General Tsev Kho Mob, Taiwan | Tuam Tshoj Medical University Tsev Kho Mob | National Cheng-Kung University Tsev Kho Mob | Kab mob siab C | Kaum Ib Hlis 2016 | Theem 3 |
| NCT01051414 | Bristol-Myers Squibb | Kab mob siab C | Plaub Hlis Ntuj 2010 | Theem 2 |
| NCT02309450 | Fab Kis Lub Tsev Haujlwm Saib Xyuas Kev Noj Qab Haus Huv thiab Kev Tshawb Fawb Kev Kho Mob-French National Agency rau Kev Tshawb Fawb Txog AIDS thiab Viral Hepatitis (Inserm-ANRS) | Bristol-Myers Squibb | Kab mob siab C Virus Genotype 4 Infection | Kaum Ob Hlis 2014 | Theem 2 |
| NCT01628692 | Bristol-Myers Squibb | Janssen Kev Tshawb Fawb & Kev Txhim Kho, LLC | Kab mob siab C | Lub Xya Hli 2012 | Theem 2 |
| NCT03186313 | Egyptian Liver Hospital|Wadi El Nil Tsev Kho Mob | Kab mob siab C | Cuaj hlis 2016 | Theem 3 |
| NCT03063723 | Third Affiliated Hospital, Sun Yat-Sen University | Chronic Hepatitis C (Kev Tsis Txaus Siab) | Lub Ib Hlis 1, 2016 |
|
| NCT00983957 | Bristol-Myers Squibb | Kab mob siab C | Lub Kaum Hli 2009 | Theem 1 |
| NCT01725542 | Fab Kis Lub Tsev Haujlwm Saib Xyuas Kev Noj Qab Haus Huv thiab Kev Tshawb Fawb Kev Kho Mob-French National Agency rau Kev Tshawb Fawb Txog AIDS thiab Viral Hepatitis (Inserm-ANRS) | Bristol-Myers Squibb | HCV-HIV Co-Infection | Kaum Ob Hlis 2012 | Theem 2 |
| NCT02282709 | Foundation for Liver Research | Kab mob siab C | Lub Ob Hlis 2014 | Theem 3 |
| NCT02032888 | Bristol-Myers Squibb | Kab mob siab C | Lub Ob Hlis 2014 | Theem 3 |
| NCT03247296 | MTI University | Kab mob siab C | Lub Ob Hlis 28, 2017 |
|
| NCT01389323 | Bristol-Myers Squibb | Kab mob siab C | Cuaj hlis 2011 | Theem 3 |
| NCT02556086 | Bristol-Myers Squibb | Kab mob siab C | Kaum Ob Hlis 2015 | Theem 2 |
| NCT01741545 | Bristol-Myers Squibb | Kab mob siab C | Lub Peb Hlis 31, 2013 | Theem 3 |
| NCT01866930 | Bristol-Myers Squibb | Kab mob siab C ntev | Lub Xya hli ntuj 11, 2013 | Theem 3 |
| NCT02268864 | Janssen-Cilag International NV | Kab mob siab C, Chronic | Lub Ib Hlis 2015 | Theem 2 |
| NCT01797848 | Bristol-Myers Squibb | Kab mob siab C | Lub Rau Hli 2014 | Theem 3 |
| NCT03166280 | Eman Sayed Hassan Abd Allah | Assiut University | Kab mob siab C | Lub Rau Hli 2017 |
|
| NCT02159352 | Bristol-Myers Squibb | Kab mob siab C | Lub Rau Hli 2014 | Theem 1 |
| NCT01125189 | Bristol-Myers Squibb | Kab mob siab C | Lub Xya Hli 2010 | Theem 2 |
| NCT03748745 | Nanjing Sanhome Pharmaceutical Co., Ltd. | Kev Sib Tham Tshuaj | Kaum Ib Hlis 19, 2018 | Theem 1 |
| NCT01012895 | Bristol-Myers Squibb | Kab mob siab C | Kaum Ob Hlis 2009 | Theem 2 |
| NCT02565888 | Radboud University | Kab mob siab C|HIV | Kaum Ib Hlis 2015 | Theem 1 |
| NCT02555943 | Humanity and Health Research Center|Beijing 302 Hospital|Nanfang Hospital of Southern Medical University | Kab mob siab C ntev | HBV Coinfection | Kab mob siab B Reactivation | Lub Ob Hlis 2015 | Phase 2 | Phase 3 |
| NCT02304159 | Tarek I. Hassanein, MD, FACP, FAG, AGAF | Southern California Research Center | Kab mob siab C | Cirrhosis | Lub Ib Hlis 2015 | Theem 4 |
| NCT02580474 | Myeong Jun Song|Bristol-Myers Squibb|Soonchunhyang University Hospital|Dankook University|Chungnam National University Hospital|Konyang University Hospital|Eulji University Hospital|Saint Vincent's Hospital, Kauslim|Konkuk University Hospital|Cheongju St. Mary's Hospital, Cheongju , Kauslim Teb | Tsev Kho Mob Severance | Kauslim University Guro Tsev Kho Mob | Eulji General Tsev Kho Mob | Lub Tsev Kawm Ntawv Catholic ntawm Kaus Lim Kauslim | Kab mob siab C | Lub Ob Hlis 2016 | Theem 4 |
| NCT02104843 | Bristol-Myers Squibb | Kab mob siab C | Plaub Hlis Ntuj 2014 | Theem 1 |
| NCT01428063 | Bristol-Myers Squibb | Kab mob siab C | Cuaj hlis 2011 | Theem 2 |
| NCT02123654 | Bristol-Myers Squibb | Kab mob siab C | Plaub Hlis Ntuj 2014 | Theem 3 |
| NCT02565862 | Radboud University | Kab mob siab C | Mob ntshav qab zib mellitus | Insulin Resistance | Lub Ib Hlis 2016 | Theem 1 |
| NCT04211844 | Ain Shams University | Kab mob siab C | Kaum Hli 1, 2019 |
|
| NCT00874770 | Bristol-Myers Squibb | Kab mob siab C | Lub Rau Hli 2009 | Theem 2 |
| NCT03883698 | Sanjay Gandhi Postgraduate Institute of Medical Sciences | Lub raum Failure, Chronic|Hepatitis C | Lub Peb Hlis 15, 2019 | Theem 3 |
| NCT01448044 | Bristol-Myers Squibb | Kab mob siab C | Lub Kaum Ob Hlis 2011 | Theem 3 |
| NCT01359644 | Bristol-Myers Squibb | Pharmasset | Kab mob siab C | Lub Rau Hli 2011 | Theem 2 |
| NCT01842451 | Vertex Pharmaceuticals Incorporated | Chronic Hepatitis C|CHC|HCV|Hepatitis C | Lub Rau Hli 2013 | Theem 2 |
| NCT02762448 | Tainan Municipal Tsev Kho Mob | Kab mob siab c | Lub Xya Hli 2016 |
|
| NCT02473211 | Humanity thiab Health Research Center|Beijing 302 Tsev Kho Mob | Kab mob siab C ntev | Lub Ib Hlis 2015 | Phase 2 | Phase 3 |
| NCT01455090 | Bristol-Myers Squibb | Kab mob siab C | Kaum Ib Hlis 30, 2011 | Theem 2 |
| NCT03490097 | Ain Shams University | Chronic Hepatitis c|Metabolic Syndrome | Kaum Ob Hlis 1, 2017 | Phase 2 | Phase 3 |
| NCT01170962 | Bristol-Myers Squibb | Kab mob siab C | Lub yim hli ntuj 2010 | Theem 2 |
| NCT02333292 | Tsev Kho Mob Valme University | Tsev Kho Mob del SAS de Jerez | Tsev Kho Mob General Universitario Elche | Tsev Kho Mob La Línea de la Concepción | Complexo Hospitalario Universitario de A Coruña | Tsev Kho Mob de Figueres | Tsev Kho Mob Universitario Puerto Real | Tsev Kho Mob General Universitario de Alicante | Tsev Kho Mob Universitario Araba | Tsev Kho Mob Royo Vilanova | Tsev Kho Mob Universitario de Burgos | Complejo Hospitalario Universitario de Huelva | Tsev Kho Mob Universitario Reina Sofia de Cordoba | Tsev Kho Mob Universitario Virgeno Viversitario de Huelva | Navarra | Tsev Kho Mob Clinico Universitario San Cecilio | Tsev Kho Mob Universitario La Fe | Tsev Kho Mob General Universitario de Valencia | Tsev Kho Mob Universitario Infanta Leonor | Tsev Kho Mob Universitario de Gran Canaria | Tsev Kho Mob General Universitario Santa Lucíaencia | Ciento ua Luz | Tsev Kho Mob General Universitario de Castellón | Tsev Kho Mob Parc Taulí, Sabadell | Kab mob siab C ntev | Kaum Ob Hlis 2014 |
|
| NCT03200184 | Tehran University of Medical Sciences | Kab mob siab C | Cuaj hlis 1, 2016 | Theem 4 |
| NCT03188276 | Third Affiliated Hospital, Sun Yat-Sen University | Kab mob siab C | Lub Ob Hlis 1, 2016 | Thaum Ntxov Theem 1 |
| NCT01830205 | Bristol-Myers Squibb | Kab mob siab C | Cuaj hlis 2012 | Theem 1 |
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