LCZ696 (Sacubitril + Valsartan)

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LCZ696 (Sacubitril + Valsartan) Lub plawv tsis ua hauj lwm Hauv    

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LCZ696 (Sacubitril / Valsartan), suav nrog Valsartan (ib qho ARB) thiab Sacubitril (AHU377) hauv 1: 1 hniav puas, yog thawj-hauv-hauv chav kawm, muaj qhov ncauj rau yug, thiab ua ob txoj haujlwm angiotensin receptor-neprilysin (ARN) inhibitor rau ntshav siab thiab lub plawv tsis ua hauj lwm [1] [2] [3]. LCZ696 ameliorates mob ntshav qab zib cardiomyopathy los ntawm inhibiting mob, oxidative kev nyuaj siab thiab apoptosis.

 

Tom Qab

LCZ696 yog thawj zaug hauv chav kawm ARNi (angiotensin receptor neprilysin inhibitor) suav nrog kev mob anionic ntawm AR valsartan thiab cov neprilysin inhibitor prodrug AHU377 (1: 1 piv) rau lub plawv tsis ua hauj lwm thiab ntshav siab.

Cov tshuaj angiotensin yog G-protein-coupled receptors. Lawv daws cov hlab plawv thiab lwm yam kev cuam tshuam ntawm angiotensin II uas yog lub cev peptide ntawm lub hlwb-angiotensin system. Neprilysin yog ib qho nruab nrab endopeptidase uas cuam tshuam endogenous vasoactive peptides xws li natriuretic peptides. Kev txwv tsis pub cov neprilysin ntau ntxiv natriuretic peptides concentration uas pab txhawb kev mob plawv, vascular thiab raum tiv thaiv. [1]

Hauv cov pob Sprague-Dawley, kev tswj hwm qhov ncauj ntawm LCZ696 ua rau qhov koob tshuaj tiv thaiv kab mob nce ntxiv hauv kev tiv thaiv kab mob ntawm atrial natriuretic peptide los ntawm neprilysin inhibition. Hauv kev ua rau ob sab sib hloov transgenic nas, LCZ696 ua rau cov koob tshuaj tiv thaiv kab mob thiab pab txo qis hauv qhov txhais tau hais txog ntawm cov leeg ntshav siab. Cov neeg koom nrog kev noj qab haus huv, muaj kev pheej hmoo, ua ob qhov muag dig, qhov chaw kawm tshuaj uas tau tshawb pom tau tseeb tias LCZ696 tau muab cov khoom xyaw neprilysin xyaw rau kev tiv thaiv thiab AT1 receptor blockade. LCZ696 muaj kev nyab xeeb thiab zoo rau hauv tib neeg. [2] [3]

Chiv keeb:
McMurray JJ, Packer M, Desai AS li al. Angiotensin-neprilysin inhibition piv rau enalapril hauv plawv tsis ua haujlwm. N Engl J Med. 2014 Sep 11; 371 (11): 993-1004.
Gu J, Noe A, Chandra P, Al-Fayoumi S li al. Pharmacokinetics thiab pharmacodynamics ntawm LCZ696, tshiab tshiab ntawm kev coj ua angiotensin receptor-neprilysin inhibitor (ARNi). J Clin Tshuaj Kho Mob. Xyoo 2010 Lub Plaub Hlis; 50 (4): 401-14.
Langenickel TH, Dole WP. Angiotensin receptor-neprilysin inhibition nrog LCZ696: txoj hauv kev tshiab rau kev kho mob plawv tsis ua hauj lwm, Tshuaj yeeb hnub no: Ther Lub tswv yim (2014),

 

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2 xyoos
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6 hli
 

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1 hlis

Tshuaj qauv

LCZ696(Sacubitril + Valsartan)

TXUJ CI NTSEEG

Quality management1

Kev Tawm Tsam 18 Cov Kev Ntsuas Xyuas Kom Zoo Kom Zoo Li Qub uas tau pom zoo 4, thiab 6 tej yaam num yog nyob rau hauv kev pom zoo.

Quality management2

Advanced thoob ntiaj teb zoo tswj system tau tso paus ruaj khov rau kev muag khoom.

Quality management3

Kev saib xyuas kev ua tau zoo khiav thoob plaws lub neej tag nrho ntawm cov khoom kom ntseeg tau tias qhov zoo thiab ua kom zoo. 

Quality management4

Pawg kws tshaj lij ntxawg koom tes txhawb nqa qhov kev xav tau zoo thaum thov thiab sau npe.

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