LCZ696 (Sacubitril + Valsartan)
Kev piav qhia
LCZ696 (Sacubitril / Valsartan), suav nrog Valsartan (ib qho ARB) thiab Sacubitril (AHU377) hauv 1: 1 molar piv, yog thawj-hauv-chav kawm, hais lus bioavailable, thiab dual-acting angiotensin receptor-neprilysin (ARN) inhibitor rau ntshav siab. thiab lub plawv tsis ua hauj lwm[1][2][3].LCZ696 ameliorates ntshav qab zib cardiomyopathy los ntawm inhibiting o, oxidative kev nyuaj siab thiab apoptosis.
Keeb kwm
LCZ696 yog thawj zaug hauv chav kawm ARNi (angiotensin receptor neprilysin inhibitor) suav nrog anionic moieties ntawm AR valsartan thiab neprilysin inhibitor prodrug AHU377 (1: 1 piv) rau lub plawv tsis ua hauj lwm thiab kub siab.
Cov angiotensin receptors yog G-protein-coupled receptors.Lawv kho cov hlab plawv thiab lwm yam teebmeem ntawm angiotensin II uas yog bioactive peptide ntawm renin-angiotensin system.Neprilysin yog ib qho nruab nrab endopeptidase uas degrades endogenous vasoactive peptides xws li natriuretic peptides.Inhibition ntawm neprilysin tsub kom cov natriuretic peptides concentration uas ua rau lub plawv, vascular thiab lub raum tiv thaiv.[1]
Hauv Sprague-Dawley nas, kev tswj hwm qhov ncauj ntawm LCZ696 ua rau muaj kev nce qib ntawm kev tiv thaiv kab mob ntawm atrial natriuretic peptide uas tshwm sim los ntawm neprilysin inhibition.Hauv hypertensive ob leeg transgenic nas, LCZ696 ua rau muaj kev noj tshuaj ntau ntxiv thiab txo qis hauv cov hlab ntsha siab.Cov neeg koom nrog noj qab haus huv, ib qho kev sib tw, ob qhov muag tsis pom, txoj kev tshawb fawb placebo tau lees paub tias LCZ696 tau muab cov kev cuam tshuam nrog neprilysin thiab AT1 receptor blockade.LCZ696 muaj kev nyab xeeb thiab ua tau zoo rau tib neeg.[2] [3]
Cov ntaub ntawv:
McMurray JJ, Packer M, Desai AS et al.Angiotensin-neprilysin inhibition tiv thaiv enalapril hauv plawv tsis ua haujlwm.N Engl J Med.2014 Sep 11; 371(11): 993-1004.
Gu J, Noe A, Chandra P, Al-Fayoumi S et al.Pharmacokinetics thiab pharmacodynamics ntawm LCZ696, ib qho tshiab dual-acting angiotensin receptor-neprilysin inhibitor (ARNi).J Clin Pharmacol.2010 Plaub Hlis Ntuj; 50(4): 401-14.
Langenickel TH, Dole WP.Angiotensin receptor-neprilysin inhibition nrog LCZ696: ib txoj hauv kev tshiab rau kev kho mob plawv, Drug Discov Hnub no: Ther Strategies (2014),
Cia
| Hmoov | -20 ° C | 3 xyoo |
| 4 ° C | 2 xyoo | |
| Hauv cov kuab tshuaj | -80 ° C | 6 hli |
| -20 ° C | 1 hli |
Cov qauv tshuaj
Tswv yim18Quality Consistency Evaluation tej yaam num uas tau pom zoo4, thiab6tej yaam num raug tso cai.
Advanced thoob ntiaj teb kev tswj hwm qhov system tau tso lub hauv paus ruaj khov rau kev muag khoom.
Kev saib xyuas zoo ua haujlwm los ntawm tag nrho lub neej voj voog ntawm cov khoom kom ntseeg tau tias qhov zoo thiab kho cov nyhuv.
Pab Pawg Kev Tswj Xyuas Kev Tswj Xyuas Kev Ua Haujlwm txhawb nqa qhov kev xav tau zoo thaum lub sijhawm thov thiab tso npe.
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