Sacubitril Hemicalcium hmoov
| 沙库比曲半钙盐 | Sacubitril Hemicalcium hmoov | 1369773-39-6 | Hauv tsev |
| 沙库比曲钠盐 | 149690-05-1, ib | Hauv tsev | |
| LCZ-4 | 1426129-50-1 | Hauv tsev | |
| LCZ-7 | 1012341-48-8 | Hauv tsev | |
| LCZ-8 | 1012341-50-2 | Hauv tsev | |
| LCZ-9 | 149690-12-0 | Hauv tsev |
Keeb kwm
AHU-377 hemicalcium ntsev yog hemicalcium ntsev daim ntawv ntawm AHU-377.Nws yog ib qho inhibitor ntawm neprilysin nrog IC50 tus nqi ntawm 5 nM [1].
AHU-377 thiab angiotensin II AT1 receptor antagonist valsartan sau LCZ696 hauv 1: 1 molar ratio.LCZ696 yog angiotensin receptor neprilysin inhibitor.Nws tuaj yeem txo cov ntshav siab thiab tej zaum yuav yog ib qho tshuaj tshiab rau kev kho mob plawv.AHU-377 yog ib qho tshuaj tiv thaiv, nws tuaj yeem hloov pauv los ntawm enzymatic cleavage ntawm ethyl ester rau hauv daim ntawv nquag LBQ657.Nws tau tshaj tawm tias AHU-377 (30 thiab 100 mg / kg, PO) tuaj yeem ua rau cov nyhuv antihypertensive nyob rau hauv cov koob tshuaj raws li DAHI-SS nas.Tab sis nyob rau hauv DOCA- ntsev hypertensive nas, nws qhia tau hais tias tsis muaj zog txo [2, 3].
Cov ntaub ntawv:
[1] Ksander GM, Ghai RD, deJesus R, Diefenbacher CG, Yuan A, Berry C, Sakane Y, Trapani A. Dicarboxylic acid dipeptide neutral endopeptidase inhibitors.J Med Chem.1995 Tsib Hlis 12;38(10):1689-700.
[2] Voors AA, Dorhout B, van der Meer P. Lub luag haujlwm ntawm valsartan + AHU377 (LCZ696) hauv kev kho mob plawv.Expert Opin Investig Drugs.2013 Aug; 22(8:1041-7.
[3] Laxminarayan G Hegde, Cecile Yu, Cheruvu Madhavi et al.Kev sib piv kev ua tau zoo ntawm AHU-377, lub zog neprilysin inhibitor, hauv ob lub qauv nas ntawm qhov ntim-nyob ntawm qhov kub siab.BMC Pharmacology 2011, 11(Suppl 1): P33.
Cov qauv tshuaj
Tswv yim18Quality Consistency Evaluation tej yaam num uas tau pom zoo4, thiab6tej yaam num raug tso cai.
Advanced thoob ntiaj teb kev tswj hwm qhov system tau tso lub hauv paus ruaj khov rau kev muag khoom.
Kev saib xyuas zoo ua haujlwm los ntawm tag nrho lub neej voj voog ntawm cov khoom kom ntseeg tau tias qhov zoo thiab kho cov nyhuv.
Pab Pawg Kev Tswj Xyuas Kev Tswj Xyuas Kev Ua Haujlwm txhawb nqa qhov kev xav tau zoo thaum lub sijhawm thov thiab tso npe.
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