Sacubitril Hemicalcium

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Sacubitril Hemicalcium   Hauv      

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KHOOM NTES

    库 比 比 曲 半 钙盐 钙盐 钙盐 钙盐 Sacubitril Hemicalcium 1369773-39-6 Hauv
    库 Tawm 比 曲 钠盐 149690-05-1 Hauv
    LCZ-4 1426129-50-1 Hauv
    LCZ-7 1012341-48-8 Hauv
    LCZ-8 1012341-50-2 Hauv
    LCZ-9 149690-12-0 Hauv

 

Tom Qab

AHU-377 hemicalcium ntsev yog hemicalcium ntsev daim foos ntawm AHU-377. Nws yog ib qho inhibitor ntawm neprilysin nrog IC50 tus nqi ntawm 5 nM [1].

AHU-377 thiab lub angiotensin II AT1 receptor antagonist valsartan sau LCZ696 hauv qhov sib piv 1: 1 hniav puas. LCZ696 yog ib qho tshuaj mob angiotensin receptor neprilysin inhibitor. Nws tuaj yeem txo cov ntshav siab thiab tej zaum yuav yog cov tshuaj tshiab rau kev kho mob ntawm lub plawv dhia. AHU-377 yog cov tshuaj txhawb, nws tuaj yeem hloov los ntawm enzymatic cleavage ntawm ethyl ester rau hauv daim ntawv nquag LBQ657. Nws raug tshaj tawm tias AHU-377 (30 thiab 100 mg / kg, PO) tuaj yeem ua rau muaj qhov tsis zoo tiv thaiv kev tsis haum tshuaj nyob rau hauv DAHI-SS nas. Tab sis nyob rau hauv DOCA-ntsev cov kev ua haujlwm siab rau cov nas tsuag, nws pom tias ua kom tsis muaj zog [2, 3].

Chiv keeb:
[1] Ksander GM, Ghai RD, deJesus R, Diefenbacher CG, Yuan A, Berry C, Sakane Y, Trapani A. Dicarboxylic acid dipeptide nruab nrab endopeptidase inhibitors. J Med Chem. 1995 Tsib Hlis 12; 38 (10): 1689-700.
[2] Voors AA, Dorhout B, van der Meer P. Lub luag haujlwm tseem ceeb ntawm valsartan + AHU377 (LCZ696) hauv kev kho mob plawv tsis ua haujlwm. Tus Kws Tshawb Fawb Txog Opin Tshuaj. 2013 Lub Yim Hli; 22 (8): 1041-7.
[3] Laxminarayan G Hegde, Cecile Yu, Cheruvu Madhavi li al. Sib piv cov txiaj ntsig ntawm AHU-377, lub zog neprilysin inhibitor, nyob hauv ob tus nas qauv ntawm ntim-tiv thaiv kev mob ntshav siab. BMC Pharmacology 2011, 11 (Khoom Siv 1): P33.

Tshuaj qauv

Sacubitril Hemicalcium

TXUJ CI NTSEEG

Quality management1

Kev Tawm Tsam 18 Cov Kev Ntsuas Xyuas Kom Zoo Kom Zoo Li Qub uas tau pom zoo 4, thiab 6 tej yaam num yog nyob rau hauv kev pom zoo.

Quality management2

Advanced thoob ntiaj teb zoo tswj system tau tso paus ruaj khov rau kev muag khoom.

Quality management3

Kev saib xyuas kev ua tau zoo khiav thoob plaws lub neej tag nrho ntawm cov khoom kom ntseeg tau tias qhov zoo thiab ua kom zoo. 

Quality management4

Pawg kws tshaj lij ntxawg koom tes txhawb nqa qhov kev xav tau zoo thaum thov thiab sau npe.

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