Kev piav qhia

Sugammadex sodium yog ib qho hluavtaws γ-cyclodextrin derivative, thiab ua raws li tus neeg sawv cev rov qab tshiab rau cov kab mob neuromuscular.

Lub Npe Lub Npe: sugammadex (soo GAM ma dex)
Hom Lub Npe: Bridion

Sugammadex thim rov qab cov teebmeem ntawm qee cov tshuaj uas tau muab thaum lub sijhawm phais kom so koj cov leeg.

Sugammadex yog siv thaum kawg ntawm kev phais, los pab kho cov leeg nqaij uas tau raug thaiv thaum phais los ntawm lwm cov tshuaj.

Sugammadex kuj tseem siv tau rau cov hom phiaj tsis tau teev tseg hauv phau ntawv qhia tshuaj no.

Nws yog siv los thim cov teebmeem ntawm qee cov tshuaj.

Hauv Vivo

Kev txhaj tshuaj sugammadex tsis muaj qhov cuam tshuam loj rau ntshav siab lossis lub plawv dhia. Tom qab txhaj koob tshuaj rocuronium siab, 90% rov qab ntawm lub tsheb ciav hlau-ntawm-plaub piv yuav siv sijhawm 28 min (SD 7 min) tom qab ntsev, 26 min (SD 9.5 min) tom qab 1 mg / kg sugammadex, thiab 8 min (SD 3.6 min) tom qab 2.5 mg / kg sugammadex[1]. Sugammadex ua rau muaj kev thim rov qab sai thiab ua tiav ntawm rocuronium-induced neuromuscular block. Lub sij hawm rov qab los rau kev cob qhia ntawm plaub qhov piv = 0.9 tom qab kev rov ua haujlwm yog 14.4 min (SD = 3.4 min; n = 14). Qhov no txo ​​qis rau 3.7 min (SD = 3.3 min; n = 4) nrog sugammadex 0.5 mg / kg thiab mus rau 1.9 min (SD = 1.0 min; n = 4) nrog sugammadex 1.0 mg / kg [2]. Qhov kwv yees ib nrab ntawm lub neej ntawm sugammadex hauv Rhesus liab yog 30 (SEM = 4.9) min[3].

Cia

Cov qauv tshuaj